Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death.

نویسندگان

  • Alexey A Nazarov
  • Daniel Gardini
  • Mathurin Baquié
  • Lucienne Juillerat-Jeanneret
  • Tatiana P Serkova
  • Elena P Shevtsova
  • Rosario Scopelliti
  • Paul J Dyson
چکیده

Two hybrid compounds comprising an antimetastatic ruthenium-arene fragment tethered to an indazole-3-carboxylic acid derivative that inhibits aerobic glycolysis in cancer cells have been prepared and evaluated in a variety of cancer cell lines, including highly relevant human glioblastoma cells, with an apparent synergistic action between the two components observed.

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عنوان ژورنال:
  • Dalton transactions

دوره 42 7  شماره 

صفحات  -

تاریخ انتشار 2013